Liothyronine Sodium T3

Abdi Ibrahim (Turkey)


Synthetic thyroid hormone

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There are three related thyroid hormones responsible for metabolism – tricodide-thyronine (L-T3), L-thyroxine (L-T4) and thyrotrophic hormone responsible for launching T4 production. Most of natural T3 is not produced directly by your thyroid gland, but rather is converted from the T4 thyroid hormone. Cytomel is a synthetically manufactured liothyronine sodium (T3)  which resembles the natural T3 hormone .

Cytomel / Tiromel (Liothyronine Sodium, L-T3)  has proven to be 4-5 times more biologically active and to take effect more quickly than levothyroxine T4. T3 has a faster onset of action as well as a shorter biological half-life, probably due to less plasma protein binding to thyroxine-binding globulin and transthyretin.

In school medicine Cytomel (Liothyronine Sodium) is used to treat thyroid insufficiency (hypothyroidism). Among other secondary symptoms are obesity, metabolic disorders, and fatigue.

T3 is not dangerous – it will temporarily shut down your natural thyroid function which can produce a lag after supplementation unless you taper correctly – it will eat muscle though, unless you are taking anavar , winny or primo while taking it. It is a great stack with clen.

Cytomel T3 in bodybuilding and fitness

Natural T3 is a regulator of the oxidative metabolism in cell`s mitochondria. Thus higher T3 level means&nbsp an increase in overall metabolic activity – your body spends more energy and burns more fat because of this. In low dosages, especially if taken along with steroids, it can even serve for certain muscle growth – due to increased metabolism. However, in high dosages it shifts towards catabolism and burns fat along with muscles.

Bodybuilders take advantage of these characteristics and stimulate their metabolism by taking Cytomel (Liothyronine Sodium), which causes a faster conversion of carbohydrates, proteins, and fats. Bodybuilders, of course, are especially interested in an increased lipolysis, which means increased fat burning. Competing body builders, in particular, use Cytomel (Liothyronine Sodium) during the weeks before a championship since it helps to maintain an extremely low fat content, without necessitating a hunger diet. Athletes who use low dosages of Cytomel (Liothyronine Sodium) report that by the simultaneous intake of steroids, the steroids become more effective, most likely as the result of the faster conversion of protein.

Cytomel (Liothyronine Sodium), is a good replacement for proviron on pre-competition cycles, especally for females. The over stimulated thyroid burns calories like a blast furnace. Those who combine T3 and clenbuterol receive synergetic effect especially because of better regulation of beta 2 receptors in fat tissue, which clenbuterol tends to deregulate. As a result these two compounds burn an enormous amount of fat.

Proper high-protein diet is important, taking non-bulking steroids like winstrol or primo is desirable while taking T3, otherwise athlete may lose too much muscle, especially while dieting.

A good stack for max results during minimal time might be Insulin, T3, AAS like primo or winstrol and HGH.


Female usage

Cytomel (Liothyronine Sodium) is also popular among female body builders. Since women generally have slower metabolisms than men, it is extremely difficult for them to obtain the right form for a competition given present standards. A drastic reduction of food and calories below the 1000 calorie/day mark can often be avoided by taking Cytomel (Liothyronine Sodium). Women, no doubt, are more prone to side effects than men but usually get along well with 50 mcg/day. A short-term intake of Cytomel (Liothyronine Sodium) in a reasonable dosage is certainly healthier than an extreme hunger diet.


Cytomel Side Effects

T3 also increases growth hormone (HGH) production, which is not bad by itself but may lead to even bigger muscle burn along with fat because HGH is also a strongly lipolytic compound, and this is another mechanism by which T3 may exert its effects. In case of T3+HGH standalone stack this may be a problem, but using some anabolic steroids is going to help with this.

Possible side effects are: trembling of hands, nausea, headaches, high perspiration, and increased heartbeat. These negative side effects can often be eliminated by temporarily reducing the daily dosage.


Dosage and Usage of Cytomel T3

As for the dosage, one should be very careful since Cytomel (Liothyronine Sodium) is a very strong and highly effective thyroid hormone. It is extremely important that one begins with a low dosage, increasing it slowly and evenly over the course of several days. Most athletes begin by taking one 25-mcg tablet per day and increasing this dosage every three to four days by one additional tablet. A dose higher than 100-mcg/ day is not necessary and not advisable. It is not recommended that the daily dose be taken all at once but broken down into three smaller individual doses so that they become more effective.

It is also important that Cytomel (Liothyronine Sodium) not be taken for more than six or max eight weeks. At least two months of abstinence from the drug needs to follow. Those who take high dosages of Cytomel (Liothyronine Sodium) over a long period of time are at risk of developing a chronic thyroid insufficiency. As a consequence, the athlete might be forced to take thyroid medication for the rest of his life.

There are some opinions that using cytomel is absolutely safe for a long time and it`s easy to restore thyroid production afterwards.

-I quote – The horror stories of people on permanent thyroid replacement just aren`t true. …people recovering their thyroid hormone relatively quickly (within months, at most) after going off of several YEARS (!) of thyroid replacement therapy. …we can safely spend an athletic career using Cytomel 9-10 months out of the year, and just taking those few months off to normalize ourselves. Is this aggressive? Yes. Is this unsafe? NO. – end of quote-

Maybe that`s true. But maybe not. So in this 50/50 situation we would advice to stay on “cowardly” side and use T3 with all precautions until the opposite will be scientifically proven.

It is also important that the dosage is reduced slowly and evenly by taking fewer tablets and not be ended abruptly.

Those who plan to take Cytomel (Liothyronine Sodium) should first consult a physician in order to be sure that no thyroid hyperfunction exists. If you have never used T3 before, it is suggested that you lessen your constant time and increase your ramp up period to determine your reaction to t3 before heavy use.

Some people wait until your thyroid shuts down in a cutting cycle (as it will when on DNP , heavy ECA , clenbuterol – anything that raises the body temp high), however, it should just be part of the whole cycle, not just replacement therapy on the end when you are on low endogenous T3.

When it`s used in a bulking cycle to help absorb all the protein – never go over 50mcg / ED, better even do 25mcg / ED. For cutting cycles dosage might be higher.

T4 may also be used to good effect with the same way but of course the dosages are different – the ratio of t4:t3 is about 4:1 or 4.5:1 so 100mcg of t3=about 400-450mcg of t4

Common approach is to increase T3 from zero to full dosage during the fists 4-7 days and then decrease at the same rate at the end. However, thyroid shuts down rather quickly, so, in order to restart the gland after the cycle it`s better to lengthen “decrease” period, for instance you spend 5% of time of increasing dosage then 40-50% of time on max throttle then remaining time on slow and even decrease of the dosage over the weeks. With this you may come to the end of cycle with warming up thyroid and smoothly finish using of tabs.

For instance, here`s an example of 3 weeks cycle and .25 tabs

4 days= 1, 1.5, 2, 3 tabs
7 days= 4 tabs
10 days = 3, 3, 2, 2, 2, 1, 1, 1, 1/2, 1/2 tabs


Additional information


100 Tabs x 25mcg Total 2500mcg, 200 Tabs x 25mcg Total 5000mcg, 400 Tabs x 25mcg Total 10000mcg



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